Tottenham moved to within two points of Premier League leaders Leicester as Christian Eriksen struck a late winner at fourth-placed Manchester City.
Visiting striker Harry Kane fired home from the spot in the second half after Raheem Sterling was controversially penalised for handball.
Yaya Toure struck a 20-yard free-kick against the bar before teenage substitute Kelechi Iheanacho levelled.
But Spurs earned a fifth league win in a row as Eriksen slotted in.
Manuel Pellegrini’s side won 21 points from their opening nine league games but have claimed just 26 points from their subsequent 17 matches.
They are six points off the Premier League summit after losing two consecutive home league matches for the first time since December 2008, and have lost ground to Arsenal and Tottenham, who are in third and second respectively.
Speaking about the controversial penalty, Manchester City’s manager, Manuel Pellegrini, said:
“It was a penalty that referee Mark Clattenburg wanted to sign for and he gave the sign. It was absolutely the wrong decision, it hit the back of Raheem Sterling then his elbow. Sterling was not even seeing the ball. It was the same referee in the first game where there were two clear goals in offside and we lost 4-1.”
“It was the key moment that decided thee game; before that they did not shoot towards our goal and did not have any chances. We took the risks, the spirit of the team was good but it was not enough.”