Real Madrid tackle Barcelona at the Estadio Santiago Bernabeu by 1pm Nigerian time.
The game is believed to have the potential to decide who will eventually win the 2017/2018 La Liga title, as Barcelona lead their rivals with 8 points to sit top of the league table.
In the game that has gradually grown to draw a global audience in the hundreds of millions, there have been some interesting facts along the way.
1. This will be the 237th El Clasico competitive game with the previous 236 editions ending with Real Madrid winning 95 games, Barcelona winning 92 games and both teams drawing 49 times.
2. There have been 33 switches of players between the Clasico rivals and some great names have played for both teams. The most famous names involved are Luis Figo, Ronaldo De Lima, Luis Enrique, Michael Laudrup, Bernd Schuster and Javier Saviola.
3. Barcelona suffered an 11-1 defeat against Real Madrid in 1943 in the competition that metamorphosed into the Copa del Rey. It’s the heaviest defeat of the rivalry.
4. Barcelona talisman Lionel Messi holds the record of most goals (24), most assists (13) and in El Clasico
5. Both teams are the most successful in Spain and among the most successful in world football. While Barcelona has 90 official trophies, Real Madrid has 89.